A list of actors who have appeared in multiple series in different roles. (Note: A work counts as a series if it has aired two or more episodes).
- Alejandra Simmons: Joan Brooke in The March Family Letters; Alex Silleg in All For One.
- Andrew Prensky: Sean Fineman in Wave Jacked; Dionysus in Pantheon University.
- Angie Lopez: Suzanna-Maria Ramirez Gonzalez in The Autobiography of Jane Eyre; Jess in Til Lease Do Us Part; Ariana Henries in All For One.
- Artoun Nazareth: Pierre in Jules and Monty; Derek Stein in Wave Jacked; Ray in High Spirits, Ajax in Pantheon University.
- Ben Stern: Jack Grayson in Wave Jacked; Hephaestus in Pantheon University.
- Carly Hayes: Jane in The Writing Majors; Stella in Horizons
- Cody McCoy: Oscar in The Writing Majors; Gil in Horizons
- Ed Rosini: Monty in Jules and Monty; Ares in Pantheon University.
- Elise Bauman: Laura Hollis in Carmilla; Bunny in Young Badlands.
- Eliot Barnhart: Stanley Hopkins in The Adventures of Jamie Watson (and Sherlock Holmes); Sebastian Messing in Twelfth Grade (or Whatever).
- Evey Reidy: Nancy in Jules and Monty; Hades in Patheon University.
- Imogen Browder: Jules in Jules and Monty; Hera in Pantheon University.
- Jennifer Catania: Jemma "The Professor" Moriarty in The Adventures of Jamie Watson (and Sherlock Holmes); Zoe in The Blair Goddess Project; Christine in Notes By Christine.
- Kaitlyn Alexander: LaFontaine in Carmilla; Dee Warson in Couple-ish.
- Kayla Mackey: Meg in Notes By Christine; Meg in The Adventures of Jamie Watson (and Sherlock Holmes).
- Kenny Weitzman: John Newman in Wave Jacked; Hercules in Pantheon University.
- Kyle Walters: Peter Pan in The New Adventures of Peter and Wendy; Ed Denham in Welcome to Sanditon.
- Mary Kate Wiles: Lydia Bennet in The Lizzie Bennet Diaries (and related); Zelda in Squaresville; Lily in Kissing in the Rain.
- Michele Herzog: Aphrodite in Pantheon University, Katie in High Spirits.
- Natasha Negovanlis: Carmilla Karnstein in Carmilla; Sallie in The March Family Letters, Ellia in Haunted or Hoax.
- Nykeem Provo: Ash in teenagers; Luke in MsLabelled.
- Richard Young: Percy in MsLabelled; Jude Khan in Sudden Master.
- Samantha Wan: Ophelia Bedelia in Ruby Skye, PI; Sera in LESlieVILLE; Alex Cheng in Sudden Master.
- Shannen Michaelsen: Sherlock Holmes in The Adventures of Jamie Watson (and Sherlock Holmes); Shannen in The Blair Goddess Project.
- Sharon Belle: Danny Lawrence in Carmilla; Rachel Mannt in Couple-ish.